Perfluorooctanoic acid (PFOA), the representative perfluorinated surfactant, is an anthropogenic pollutant detected in various environmental matrices. Little is known regarding its safe thresholds to the aquatic ecosystem. Predicted no-effect concentrations (PNECs) for PFOA were derived based on the measured/predicted chronic/acute toxicity data. The interspecies correlation estimation (ICE) program and final acute-to-chronic ratio (FACR) were applied to investigate their capability for the derivation of PNEC. The recommended aquatic toxicity thresholds for PFOA are in the range of 0.30 ~ 8.48 mg/L. The ICE-based species sensitivity distribution (SSD) method has certain potential for the derivation of PNEC especially when toxicity data are limited.
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