Oral, subcutaneous and intratracheal administration of carcinogenic lactones and related substances: the intratracheal administration of cigarette tar in the rat.


IT has now been possible to test 33 compounds with a lactonic or related structure, of which 25 have proved on subcutaneous injection to be capable of inducing the formation of tumours of the connective tissue elements of rats (Dickens and Jones, 1961; 1963a, b; 1965). The carcinogenic substances are for the most part characterised by chemical structures which indicate their reactive nature. This may be due to:


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